Histopathological changes in the liver after allogeneic bone marrow transplantation

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Histopathological changes in the liver after allogeneic bone marrow transplantation.

Postmortem and surgical specimens of liver from 20 patients who had undergone allogeneic bone marrow transplantation for a variety of disorders were examined. The lesions fell into five major categories: bile duct atypia often associated with portal tract fibrosis (8 cases), veno-occlusive disease (2 cases), small foci of non-zonal hepatocyte necrosis (3 cases), opportunistic infections (3 case...

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Sir, Vitiligo is a common, depigmenting disorder characterized by well-circumscribed cutaneous macules devoid of melanocytes on the epidermis. Bone marrow transplantation (BMT), which has significant therapeutic benefits in haematologic disorders, such as leukaemia and aplastic anaemia, provides convincing evidence for the role of the immune system in some autoimmune diseases (1). In this repor...

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Allogeneic Bone Marrow Transplantation

A 1 3-yr-old male with acute myelogenous therapy. Then, 53 yr later, he developed leukemia was treated with various chemoan extramedullary relapse with a chlotherapy regimens for 3 yr and then underroma of his maxillary sinus. This case ilwent an allogeneic bone marrow translustrates the need for prolonged followup plantation. The donor marrow was sucof transplant recipients and suggests that c...

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Cytomegalovirus infection after autologous bone marrow transplantation with comparison to infection after allogeneic bone marrow transplantation.

Cytomegalovirus (CMV) infection was detected in 65 of 143 (45%) autologous bone marrow transplant (BMT) patients. CMV pneumonitis occurred in only 2% of the patients and CMV retinitis occurred in none. Infection occurred in half of the 40 initially seronegative patients and 47% of the 94 initially seropositive patients. Among initially seropositive patients, platelet recovery was slower in infe...

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Antibody-mediated marrow failure after allogeneic bone marrow transplantation.

Marrow graft failure observed in association with histocompatibility differences between donor and recipient is often attributed to rejection mediated by host-derived cytolytic T lymphocytes. The data presented in this report indicate that persistent host antibodies specific for donor antigen may also mediate graft failure, either by antibody-dependent cell-mediated cytotoxicity (ADCC), or comp...

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ژورنال

عنوان ژورنال: Journal of Clinical Pathology

سال: 1980

ISSN: 0021-9746

DOI: 10.1136/jcp.33.4.344